* memory IC failure
* power delivery component failure
* dead core
* cracked BGA solder joints on core
* damaged PCB due to sag
These issues are compounded by
* huge power consumption and heat output of core and memory, compared to system CPU/memory
* physical size of core leads to more potential for solder joint fracture due to thermal expansion/contraction
* everything needs to fit in PCIe card form factor
* memory and core not socketed, if one fails (or supporting circuitry on the PCB fails) then either expensive repair or the card becomes scrap
* some vendors have cards with design flaws which lead to early failure
* sometimes poor application of thermal paste/pads at factory (eg, only half of core making contact
* and, in my experience in aquiring 4-5 year old GPUs to build gaming PCs with (to sell), almost without fail the thermal paste has dried up and the card is thermal throttling