Show HN: Best biological age model using standard blood tests (opens in new tab)

(longevity-tools.com)

1 pointszsolt2245mo ago1 comments

There’s a fairly recent research paper introducing a biological age calculation model, that uses only standard blood tests and outperforms PhenoAge. So I reached out to the original researchers and did a 1-hour+ interview with one of the authors. I developed an online calculator based on it and we came up with a name for it: "Bortz Blood Age Calculator"

*About the model:*

- Trained on 306k individuals from the UK Biobank database - Validated on similar dataset - It offers an 11% relative increase in predictive value over the Levine PhenoAge - This model includes better markers (like Cystatin-C, ApoA1...) compared to other similar models. - Interesting thing is that the model selected for higher total cholesterol, ALT and creatinine as better. More about it later.

*Online calculator:*

Based on the model, I created 100% free and private online calculator: https://www.longevity-tools.com/humanitys-bortz-blood-age

*Video*

I also made a video about the calculator, which explains:

- more info about the model and how it was created - gotchas of the calcutor - some speculation about why the model selected for higher total cholesterol, ALT and creatinine

Video link: https://www.youtube.com/watch?v=2VHIfouvcYE

*Research paper link:*

https://www.nature.com/articles/s42003-023-05456-z

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I do not sell anything or promote anything paid. This is not a medical advice.

1 comments

drewbitt5mo ago

I know you say "Each country have different lab panels. So individual biomarkers are listed instead of panel names.", but it would be nice to have 'the optimal guide' of labs to run to get all of this as cheaply or as combined as possible. I likely can't use this tool as I don't have all these lab results. In the US it would be at least a CBC with differential, a CMP, lipid panel, A1c, GGT, hsCRP, Vitamin D and a couple more.

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