If it's an open clone that can be reasonably distinguished from software side and from looking at the part and it doesn't violate IP laws other than software patents, no biggie.

Every clone of any sufficiently complex Thing will have subtle quirks and edge cases compared to the original and as long as I can work around them for only that specific clone model, that's easy.

But clones that have no way of determining if the part is a clone? That's bad to even exist because unscrupulous actors will go and repackage "legitimate clone" chips into faked originals if the price difference is big enough.