House of Leaves is something I've been wanting to read since I first saw it, but I've never had the chance. Unlike most books, I feel that I'd be missing out on a lot if I didn't read it in physical form.
Yes, it's definitely something you want to experience in the physical form! It's hard to describe what reading it feels like towards the latter parts of the book- you feel like you're lost in the book like how the Navidson gets lost in the house.
I keep track of my Emacs with a Tractive GPS collar, and I have an app on my phone that shows the trails and a heat map of everywhere he's been. And I debug him with Frontline, but that doesn't prevent him from coming in with slugs in his fur. (Emacs is my cat's name.)