This is well researched and just like with semaglutide I believe a big part of the population should take daily tadalafil.
Better cardiovascular health, more erections and many positive downstream effects (lower E:T ratio, weight loss) that are beyond the scope of this comment.
One of many, looking at just one detail (sitting): https://www.health.harvard.edu/staying-healthy/sitting-may-i...
From a personal experience, so it's just a guess, a contributor may be fluid movement in the body. Fluid in blood vessels are pumped directly, but must fluid is not in blood vessels. The heart has a diminishing effect outside the vessels (capillaries have small holes to let water and small molecules through into extracellular space, and then to collect it back, rest goes through the lymphatic system which also drains back into the bloodstream). Muscle and body movement helps. From what I experienced and experimented, just walking did a lot more than running. I focus on this specifically due to personal health experiences that I don't want to go into that let me feel a clear difference, where intensive running did hardly anything but then just walking did, an experiment I performed during a period of my life when "getting stuff out from all over my body" mattered.
Personally, I choose to run only when my brain/body tell me to, when I feel like it. Definitely not when I would have to fight myself to get going. (If your body/brain tells you the opposite then it is what it is, personal feel over generic advice)
Every person has a limit of how much time and energy they can put into exercise. If they can go beyond that with a pill (with no other cost), why wouldn't you want everyone to take it?
5mg daily tadalafil is fine for me though and that‘s also the normal daily dosage.
Emily Austin, Hilary S. Myron, Richard K. Summerbell, Constance A. Mackenzie, Acute renal injury cause by confirmed Psilocybe cubensis mushroom ingestion,
Medical Mycology Case Reports, Volume 23, 2019, Pages 55-57, ISSN 2211-7539,
https://doi.org/10.1016/j.mmcr.2018.12.007. (https://www.sciencedirect.com/science/article/pii/S221175391...)
Abstract: Psilocybe mushrooms are consumed for their hallucinogenic properties. Fortunately, there are relatively few adverse effects associated with their consumption. This is the first reported case of acute kidney injury (AKI) secondary to confirmed ingestion of Psilocybe cubensis mushroom. A 15-year-old male developed symptomatic AKI 36 h post-ingestion of Psilocybe cubensis mushrooms. He was admitted to hospital with hypertension, nausea and abdominal pain and a creatinine of 450 mmol/L. A sample of the crop of mushrooms was confirmed by mass spectrometry to contain psilocin. On day 5 post-admission, he was discharged home. Outpatient follow-up confirmed complete resolution of his renal function.
Keywords: Psilocybe; Nephrotoxicity; Mushrooms; Kidney injury