x86 ISA had the funny advantage of being way closer to RISC than "beloved" CISC architectures of old like m68k or VAX. Many common instructions translate to single "RISCy" instruction for the internal microarchitecture (something AMD noted IIRC in the original K5 with its AMD29050-derived core as "most instructions translate to 1 internal microinstruction, some between 2 to 4"). X86 prefixes are also way simpler than the complicated logic of decoding m68k or VAX. An instruction with multiple prefixes will quite probably decode to single microinstruction.
That said, there's funny thing in that Transmeta tech survived quite a long way to the point that there were Android tablets, in fact flagship Google ones like Nexus 9, whose CPU was based on it - because nvidia "Denver" architecture used same technology (AFAIK licensed from Transmeta, but don't cite me on this)