What nicotine does to your brain (opens in new tab)

I caught covid for the first time in jan of 2024, the illness itself wasn't that bad for me, like a common cold, but the aftereffects lingered for months. Eventually my ability to smell and taste came back in a few weeks, but the mental brain fog would not let go. I would sleep over 12 hours a night and still be tired. According to my fitness tracker my daily step and energy burn counts were cut in half. It was so bad I forgot my own phone number at one point and my gmail password. Looking at a screen of code was impossible, I couldn't focus for more than a few seconds. My friends commented on the noticeable changes in my acuity and behavior.

Based on some online anecdotal evidence, I decided to try nicotine "therapy". I bought 4mg smoking cessation mints, cut them in half with a pill cutter, and took 10-12 2mg doses per day at roughly one hour intervals. The effect was immediate and brain fog lifted in less than a week. It was like coming out of a long dream, or like I had been stoned for six months and then suddenly I was sober again. My fitness stats have exceeded where I was before I got sick.

This is just my own anecdotal experience, and there have definitely been some downsides. The mints are about $50/month. My dosage has ticked up a bit and I'm certainly addicted, at least once a day I take a full mint instead of a half for an extra kick. I'd like to taper off, but I'm not sure if I do how to know if any effects are withdrawal or resumption of the covid brain fog. I have a light caffeine habit (2 cups every morning) and I don't see the mints being any more harmful than the coffee, so I think I'm just going to stick with it.

I am diagnosed ADHD. I have used dexamphetamine as prescribed which worked pretty well, in moderate dosages because I am sensitive, but I came to dislike the effect it had on me: I felt like I was attached to a horse that kept pulling me around even when I just wanted to stop and take a break. And the fact that I would crash 5 hours later.

In 2020, before even knowing I had ADHD, let alone being medicated, I managed to quit my (vaped) nicotine habit after using progressively smaller patches; meanwhile my executive dysfunction grew so much, during the most stressful time of my entire life, that I literally had a major nervous breakdown. It took years of therapy, diagnosis with ADHD, medication, to connect the two factors: I had been self-medicating with nicotine by entire life, and as I reduced the amount of it in my bloodstream, the more scattered I became [1]

Then I tested my theory: I bought some nicotine patches, cut at very low dosage. And lo! it was as effective as dexamphetamine was, with much fewer of the side-effects, no pulling effect [2] and cheaper. It's been now a year and a half and honestly it's been working great. I slap on a small patch in the morning, it lasts MUCH longer than a pill, and it even allowed me to move and still lead a productive life in a country where ADHD is not even recognised. I asked my psychiatrist and they confirmed that nicotine is known to work as a third-line medication but usually amphetamines are preferred.

This is not medical advice, yadda yadda, but worked for me, and I've always wanted to write a post about it. Regarding addiction: pretty much none, patches take too long to take effect to create addiction (i.e. caused by a predicable spike in dopamine). My dosage (~7.5mg patch cut out from a larger one) has been the same for the past 18 months, and trying larger doses just makes me sleepy (nicotine has a U-shaped effectiveness curve). Nicotine is much maligned, but if you do the research, avoid the smoking and inhalation devices but only use patches, maybe you'll find it helps you as well.

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1: I read that cigarette smoke during the formative years is associated with lifelong ADHD, and my pet (silly) theory is that the increasing stigma surrounding smoking of the past ~30 years might be one of the many factors we see ADHD on the rise. We might have 2 or 3 generations of smoking parents that were themselves self-medicating because of growing up in times where smoking was commonplace.

2: if I need to feel like a productive machine for a couple hours, coffee and a tyrosine pill can recreate the amphetamine feeling pretty well

Compare and contrast https://gwern.net/nicotine

I can't read the article unfortunately.

However nicotine also seems somewhat palliative to a range of mental illnesses like schizophrenia, bipolar, anxiety, etc. I once read a paper that said something like 90% of schizophrenics were chain smokers who were self-medicating.

By that lens the widespread amount smoking in the past makes sense in eras before other pharmaceuticals.

I take 2mg gum 0 to perhaps 8 times a day. Usually 2-3.

When box empties, I take a week or two off.

Slightly sharpens thought and suppresses appetite in combination with caffeine. Helpful for getting reducing body fat and getting abs in my advanced age. Supposedly neuroprotective effects as well.

There's also this short video from Kurzgesagt about smoking (nicotine) about this topic

https://youtu.be/_rBPwu2uS-w?si=VPqKyty7I96jtKj4

TLDR;

• Nicotine boosts attention, memory and alertness by releasing dopamine and other neurotransmitters.

• It’s far less harmful than tobacco but highly addictive.

• Some evidence hints at therapeutic effects in Alzheimer’s, Parkinson’s and schizophrenia models.

• Developing brains (foetus, adolescence) show lasting harm in animal studies.

Brain fog for me became a lot less prevalent recently. I got no idea what it is but I don't want it to stop.

I honestly think brain fog is mostly a mentality thing, but I have no evidence to back this up. It doesn't really matter what I eat. The only thing I changed was I started gymming again and I'm taking creatine. I still eat garbage food

It does seem to help with focus, but my attempts to curb adhd and brain fog happily didn’t stop at nicotine. Niacinamide (B3) seems to do much better job for me, without the smell, nausea, and it works longer.

Honestly, now that you have all-white snus, basically all of the issues of cigarettes are gone (and they are so fking expensive in Europe) and you get all of the benefits of nicotine. I don't need to go outside the office, just sit at my desk and continue working. Now that the market is developed you can vary nicotine dosage at will.

Maybe someone else here heard something different, but my dentist told me that there don't seem to be any dental issues associated with oral pouches, at least so far ?

... we'll never know from this paywalled article