Javascript was a weird exception, being rigidly the only thing available in the browser for so long and thus the only acceptable "compile target" for anything you want to run in the browser. In general I can't name very many instances of "write in X and compile it to Y", for some Y that isn't something you are forced to use by a platform, being all that successful. (See also assembler itself.) The Javascript world gives a false signal of this being a viable approach to a project; in general it doesn't seem to be.
(Note this is a descriptive claim, not a normative one. I'm not saying this is how it "should" be. It just seems to be the reality. I love people trying to buck the trend but I am a big believer in realizing you are trying to buck a trend, so you can make decisions sensibly.)
The other option is to evolve static python into such a language. Looking forward to the PEP that proposed DSLs in Python.
- https://github.com/danielgtaylor/huma then OpenAPI -> TS
- https://github.com/gzuidhof/tygo
- https://github.com/coder/guts
guts also does some AST stuff.
It seems like this project could help with this and then some.