My understanding is that the only still-lifes known not to have a glider synthesis are those containing the components listed at [0], which are 'self-forcing' and have no possible predecessors other than themselves. Intuitively, one would think there must be other cases of unsynthesizable still-lifes (given that a still-life can have arbitrary internal complexity, whereas gliders can only access the surface), but that's the only strategy we have to find them so far.

[0] https://conwaylife.com/forums/viewtopic.php?f=2&t=6830&p=201...