I don't believe doors and physical access in general need to be rethought, except maybe to improve the security of physical locks themselves. The 'big dumb thing between you and my stuff you'd need a sledgehammer to get past without a key' model has mostly worked for a good long while. (Or, fine, a crooked bit of wire if you're clever.) Why does that need to be disrupted?
We are moving towards a world where everything is connected, online, and accessible. Doors and keys are not in need of an overhaul, but some day, due to advances in peripheral technologies, having a door unlock automatically is going to just seem obvious. At first it will be something only the newest buildings have, and eventually, old metal keys/locks will be something only the oldest buildings have. Do you believe that doors/locks/keys are going to be unchanged in the next 50 years?
A ubiquitous system for locks that somehow can identify you by proximity, can also be used to track your movements and whereabouts. Networked locks could be theoretically controlled from a remote location, leaving someone else to act as, essentially, the systems administrator for your physical access privileges. This is what they do in prisons. Applying the concept of separating someone from direct control over their physical access-space to a large scale, and it looks a bit ominous - at least if this assumes these network locks are also commonplace on cars, houses, hotel rooms, hospital rooms, etc. This is not even considering what happens when power goes out, or the network goes down. Physical locks still work without electrical power, and the tumblers only care about the piece of metal that's currently jammed into the slot and whether it moves the pins properly... principle of least privilege.
I can see this sort of thing becoming somewhat more commonplace but I also see its spread as self-limiting. E-books aren't going to replace physical books, the internet isn't going to replace television, which hasn't replaced radio, which hasn't replaced theatre. In each case, the newer version of the technology does provide their own advantages and enhancements of the medium but not to the degree that the older, less complex version no longer has relevance. The future is never going to be that evenly distributed, this I believe. In a hundred years, some people might be genetically engineered posthuman cyborgs linked to a quantum hivemind, but someone, somewhere, will be living in village of mud and stone. People will still use physical locks because there's no real reason for most people not to. They could theoretically still work in a hundred years. Software doesn't age nearly as well as a steel bar through a door jamb.
Nearly all locks can be picked. However, unless you are the target of a major criminal organization or government agency, it is reasonable to expect that your lock will not have to withstand someone who has invested thousands of hours into learning how to pick the most sophisticated locks. With a network-connected device, it only takes one clever fellow to discover the vulnerability and all of a sudden script kiddies everywhere can be deploying it against your lock.