The difference is that (mostly) in a deadly airline incident the pilot(s) aren't around to take the blame (or credit!) for their actions. In the case of a computer operator running a computer program irresponsibly, almost always said computer program doesn't kill the operator.

We don't require hundreds of hours of training and education to operate a computer. You can just go to the store and buy one, plug it in, and run whatever software you want on it.

So there are quite some differences between these scenarios. In my view if you run some program on your computer, you're responsible for the consequences. Nobody else can be. And don't say you didn't know what the program would do--if that's the case you shouldn't have run it in the first place.