One business domain that Rust currently doesn't have an answer for, is selling commercial SDKs with binary libraries, which is exactly the kind of customers that get pissed off when C and C++ compilers break ABIs.
Microsoft mentions this in the adoption issues they are having with Rust, see talks from Victor Ciura, and while they can work around this with DLLs and COM/WinRT, it isn't optimal, after all Rust's safety gets reduced to the OS ABI for DLLs and COM.