>Smallpox, which the only remaining samples exists in a couple of secure facilities controled by superpowers...
I used to believe that, too, until the Russians found a few vials in a random storage cabinet. The fact is we have no idea how many samples exist and where they all are.
Fortunately, we already know how to make a smallpox vaccine.
Not only that, but we have currently functioning distribution networks for pox vaccines. AIUI, the MPox vaccine is just a smallpox vaccine that happens to also work for MPox.