I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in this study appear to be in the same range where things start getting really disrupted in cells.
In other words, don’t expect to replicate these results with normal recreational use.
this would require 3 joints of ~ 300 mg cannabis at ~ 30% THC content.
the legendary MTF strain regularily trumpets a 25-30% THC content.
now if bioavailability is 30% that means you need 9 or 10 joints to get a 1 micro molar total dosage. that dose is distributed across body mass.
at this point, i cant say i could conceive of anyone smoking basically an 1/8 ounce of MTA in one day, let alone at one sitting, and doing that for 6 days in a row sounds frightening, not recreational.
Actually, I think even by 2016 we already had enough phase 3 drug failures that the amyloid hypothesis was severely called into question?
https://pubmed.ncbi.nlm.nih.gov/41160460/#:~:text=ResultsAt%...
https://www.nebraskamed.com/health/conditions-and-services/n...
But somehow I doubt it will be found to be that effective.
But fortunately there's a much better solution for those of us who get anxiety from weed, it's called "don't smoke weed".
Now that it's legal and everywhere, I just get super fun panic attacks. I'm worthless, I'm failing as a parent, everybody hates me, you know, the normal anxiety attacks. Even Charlotte's Web that's SUPER low THC gives me panic attacks.
It's like my body hates it when I'm happy? I would give anything to be able to fix this problem.
If you end up smoking high percentage THC with little to no CBD, those who with tactile brains will enter a state of negativity. Anxiety, paranoia et cetera.
Essentially just roll CBD leaf only with your main THC leaf and this should equal the balance but again this is all anecdotal and myself as experiment.
I hate being truly high, but a weed "buzz" is great for falling asleep, especially when ill (I often suffer more from severe lack of sleep than from any of the other effects of whatever common virus or bacterial infection I manage to catch). It doesn't take much for a lightweight (a status I have carefully maintained) to reach "buzz" territory, and only a little more to reach "properly high" territory (which, again, I find rather unpleasant).
I'd suggest edibles and starting at 2mg, max, for a first attempt, working up 1mg at a time (in a totally different session, on another day!) until desired effect achieved. Like I've been at this a while and a 10mg gummy, which is a common single-gummy dose size in many states, will take me past where I ever want to be. 5ish is about right for me, maybe up to 8 if I need a stronger kick for some reason (like, say, I'm sick and need to get high enough to sleep most of the night despite significant sinus discomfort or throat pain)
FWIW I also doubt the anti-Alzheimer's stuff will pan out, or if it does, it'll be some targeted therapy with specific chemicals, which won't look a lot like any products from a dispensary.
https://news.harvard.edu/gazette/story/2010/03/alzheimers-as...
And also, apparently, the registered trademark?
> The researchers found that high levels of amyloid beta were associated with cellular inflammation and higher rates of neuron death. They demonstrated that exposing the cells to THC reduced amyloid beta protein levels and eliminated the inflammatory response from the nerve cells caused by the protein, thereby allowing the nerve cells to survive.
Standard disclaimers apply.
Cannabis really needs a lot more study.
No, it has not improved my memory. Though, I am not really certain anything does. At least, not permanently. Though, I will say the effects on memory are rather complex. Some diminished abilities in some domains, but oddly some enhancements in a select few domains.
I am 'neurodivergent' apparently, so my experiences might not be worth much.
In my defense, it may have been a stupid joke but it's not as stupid as trying to prevent brain damage by taking cannabinoids at levels known to cause brain damage.
Here. Take my upvotes to balance it out a smidge.
