1. Packages should carry a manifest that declares what they do at build time, just like Chrome extensions do. This manifest would then be used to configure its build environment.
2. Publishers to official registries should be forced to use 2FA. I proposed this a decade ago for crates.io and people lost their minds, like I was suggesting we drag developers to a shed to be shot.
3. Every package registry should produce a detailed audit log that contains a "who, what, when". Every build/ command should be producing audit logs that can be collected by endpoint agents too.
4. Every package registry should support TUF.
5. Typosquatting defenses should be standard.
etc etc etc. Some of this is hard, some of this is not hard. All of this is possible. No one has done it, so it's way too early to say "package managers can't be made safe" when no one has tried.