Yes, I still use it and can confirm that I have had no concerns or problems with it. On the other hand, if I had to reinstall, without research, I'm not sure how I would reinstall it. Having alternatives is a good thing.
I have had frequent enough issues with it silently blocking some things with no ui exposure of those blocks. Been a while now, but I think it was stuff like webrtc and other more "arcane" features.
Indeed, this is why I eventually stopped using it; sometimes a random site wouldn't function properly, and took time to figure out it was uMatrix. It was a nice plugin indeed though.