Nope. I want to get the most out of all cpus that will run my code. This is a combinatorial problem that grows exponentially by the number of relevant extensions. So, yes, you need to know the hardware, but accounting for combinations of 5 features is way easier than accounting for combinations of 10 features.

Riscv is basically repeating the same mistake X11 did. A minimal base that could be varied endlessly by combining extensions. I didn't work for X11. Some extensions became de facto mandatory (shm) while others fell by the wayside. But you could never rely on the availability of a given extension because someone somewhere might not have had it or disabled it. Then Wayland came along and cleaned up the gazillion extensions mis-design because it was a huge PITA. Riscv will get there too, sooner or later.