One example is the Canadian charity One4Another which performs surgeries to reverse some common birth defects in kids and babies in Uganda. They're not trying to feed the world, they're not interfering with the local economy; in fact they're employing doctors and nurses to perform a one-time intervention that changes the life of thousands of kids a year in the catchment area of their facility.

Obviously there are things that a group like this can't do but a massive NGO can, and that's great too, but for what I have to give, I feel very good about the impact per dollar of this.