I was really hopeful of kivy [
http://kivy.org/], but after playing around with it a little bit, it seemed very foreign to me, even though I program in Python daily. It seems very un-Pythonic, for lack of a better term.
On top of that, it seems to focus more on 3D than 2D, which is probably why there's so much there I'm less familiar with, but I mostly just want a decent 2D interface in Python.
I've had the best luck out of things like AppCelerator and Phonegap, but I've never been thrilled with the performance of either.
