path prefixes only generally apply to ./configure scripts when you are generating makefiles.
As paths to libs and stuff are hardcoded as part of the ELF spec, it becomes difficult to implement something like this and ive not seen a package manager that can do it.
theoreticly you could work around the library/datafile issues with LD_PRELOAD hacks to make it load stuff from your home directory instead, but thats pretty awful.
