There would be a lot of factors to consider that might make it hard to apply to re-valuing Scrabble, though:

1. Most Words With Friends play is casual, and casual players are likely to play very differently than competitive players.

2. The data would show you what words players play given the current scoring system, and wouldn't necessarily translate to another scoring system.

3. Words With Friends is a different game than Scrabble (different board layout, different bingo scoring, different number of tiles and different tile frequency).

4. Players end up playing the majority of the tiles they draw, so the frequency with which they play a letter may have a closer relationship to how many of the printed tiles have that letter than it is to the frequency of the letter in the corpus.