All the kernel modules of my desktop sum a few KB. Only in 1 system I see "nvidia" is a big module, but it doesn't use to be loaded in virtual machines.
About the blacklisting method... I use to never touch the distribution files inside /etc/modprobe.d (to ease upgrades, differences across hosts, etc).
I think it could be better to use something like /etc/modprobe.d/local.conf or hostname.conf
And note, that the "blacklist" directive, by side effects, may avoid module autoloading at boot time, but the real way to disable a module (forever) is to use this instead of "blacklist":
install modname /bin/true
For more information, see blacklist in: man 5 modprobe.dI did expect to see more tips about "userspace" configurations, where it's more easy to win MB instead of KB.
At kernel level... after change the kernel for one more light, and tune which modules are loaded... if we go for details... still you could see which params are available for loaded modules (some params may affect ram usage) and which sysctl values we can tune in the kernel (buffers, limits, etc) to affect ram usage.
http://ubuntu-smoser.blogspot.co.uk/2013/02/using-ubuntu-clo...
Also, Tinycore linux might be great but I would like to use Ubuntu for convenience and keep my existing additional scripts and provisioning profiles compatible.
I'll have a look at Tinycore Linux though, thanks for mentioning.