That looked like a fun skill to have, so I tried doing it on my own - introducing myself to other attendees, asking about their work and projects, etc. And I ran into a bunch of awkward situations where the person responded as if I were flirting with them (inevitably most of the people I talked to were men, since most of the people at those conferences were men). No, I actually just wanted to learn more about your company's business model.
I was copying my male friend's style of talking to other men, and I was interpreted differently. I've adjusted my approach now to reduce the chances of misunderstandings like that.
A subtext that you may have missed is that it's very awkward and uncomfortable to have only one party to a conversation think that the conversation is sexually charged, and the possibility of that happening is a disincentive to circulating and socializing.
I thought it was a pretty straightforward observation, but hopefully my summary helps you. Translating basic human experience to nerd-ese --- all part of the service we provide!
I am also more serious when I'm talking to people I don't know - less smiling, more matter-of-fact, cool instead of warm. This is artificial for me since I'm generally friendly, but apparently it's less confusing.
I spend a lot more time reading the situation to get a better feel for how people are likely to respond, including whether people at the conference/event are likely to already have a reasonable amount of experience working/talking with women as peers.
Or I find ways to meet new people while I'm with other people, such as joining groups that have positioned themselves to be open to others joining in. Or convincing friends - or people I've just met - to tag along with me to meet other people.
It's fairly unlikely in a civilised surrounding, but civilisation is rarer than you think.
As a straight white male, your potential downside from getting into a chat with someone at a party does not include serious bodily harm. Most people are nice to you by default.
Another example: an outgoing, alone woman might be perceived as easy or sleazy by some Neanderthal-like person she talks to, and could end up with a lot of unwanted attention from saying hi to the wrong people. Again, unlikely, depends on the surroundings/crowd, but still.
As a white straight guy, going to a totally random party alone is a much safer proposition.
As a white, cis, straight male (with a good job, I might add) there are few venues you aren't automatically welcome at and compatible with.
Flip any of those variables and "just get out there" is less applicable or harder. It's not like being a white male is a cheat code at life, but you spawn with a fuller inventory and a couple rings of +2 less bulshit.
Reality is it applies to everyone and its just a "woe is me" strategy. I "can't" socialize because I'm not pasty white, well there's a load off my back I don't have to be responsible for anymore.