Take land mines. I've heard that they play a critical role in South Korea's defense, which was a major reason Clinton didn't sign. Military experts talk about how it's an effective tool that, when used responsibly, can benefit civilians more than harm them.
They also kill and maim people.
Intellectually, both sides seem reasonable to me. Of course, emotionally, one is passively helping people (or so we are told), while the other is actively harming them, so, ya, I lean towards being anti land mines. But, I fundamentally can't shake the feeling that I have no clue what's going on, so maybe I shouldn't be too quick to judge.