The ethics of messing with people are not the main barrier, they are no barrier. It's the legal restrictions - the government regulations which make any kind of messing with perfectly willing humans very costly and time intensive.
Since you're all about decreasing the cost of experiments and regulation for humans though, I take it you are going to be one of the first to sign up for the next generation of human experiments that have little to no regulatory standards?
Yep.
But willing volunteers are not in shortage and are also no barrier to the advancement of science. It is once again the regulations, their cost is to the cost of paying human drug testers as Everest is to an ant hill.
In other words: You can't give me what I want, because the government is protecting me from me. Only in recent years has the FDA been willing to soften its restriction if I happen to be dying, but even then only if I'm really close to the end. Then I can legally try the cutting edge drugs.