Xamarin is really the "killer app" for .NET at the moment. Being able to use a common codebase for Windows RT, Windows Phone, Windows, OS-X, Android, iOS is amazing. Being able to do full native work on top of that on every platform. The apps look, feel and act native cause they are using native widgets.
Last I checked the F# supports was still a little crufty (over a year ago) -- but if they really get the F# support to be top tier, I will have to return and have another look.