I find them fatiguing.
I cannot get past the Koss KTXPRO-1. They're very inexpensive, but I can mix on them, they're comfortable and priced very well. There's no fatigue with them.
I really do throw a rough up first on the 'phones because it seems to get me to a decent first mix fast.
I need to buy a nice pair of Grado and/or Stax just to try to wean myself off these things. :) Don't mean to sound fanboiish, but I've used 'em now for going on fifteen years. Headphones are like that.