And yet, to this day, Firefox has both Ctrl-Q (close all Firefox windows without prompting) and its neighbor Ctrl-W (close current tab) and refuses to change that or provide remappable keyboard shortcuts. One of the biggest UI failures I'm aware of in 2014.
Ctrl-Q exits on Thunderbird too. Since in MS Outlook that combination marks a mail as read, for keyboard-heavy users switching between the two, it is no fun.