well, other than a table cell can't drop down below the previous elements of its row if the viewport width shrinks past certain points.
What I mean is that tables are not "responsive" and laying things out with tables, while "easy" was not enough for anything more than people browsing the web on CRTs, and certainly not for thousands of different displays with varying dimensions and resolutions.
Things are good these days. You can still use tables if that's as far as you want to go, or you can do things professionally.