Still, modern launch vehicle human ratings were only developed after the second Shuttle disaster, and are far beyond 1965 standards.

http://nodis3.gsfc.nasa.gov/displayDir.cfm?Internal_ID=N_PR_...

Falcon 9 v1.1 is almost certainly safer than the Titan II Gemini Launch Vehicle. As with prior Dragon flights, humans could have flown and been just fine.

It's comparable to any consecutive launches that occurred in the nearly five decades since.