- Buying things that people would be unwilling to sell to you with existing payment methods due to fraud risks. One legal example: iPhone purchases shipped to Nigeria.
- Buying things electronically where the existing payment methods are too slow or expensive. For example, funding a stock trading account in seconds to an hour instead of 1-2 days or funding an online gambling account (legal for most non-US residents but slow and expensive with credit cards).
- Buying an expensive item from a trusted merchant at a discount commensurate with the reduced transaction cost and zero chargeback risk.
- Paying for contractors or crowd-sourcing efforts in any country in the world with ease.
Use your imagination.