If you're not so serious that you're willing to manually encrypt and decrypt files (or ZIP archives of files), just use your OS's full disk encryption scheme. On a Mac, for instance, you can create virtual disks with AES-XTS and keys derived from passwords; that's built into the OS.
What people really want is some kind of transparent encrypted filesystem. That's a reasonable thing to want, and it would be more secure than Truecrypt. I don't know of a good one.