If you go through the Chrome bug tracker, you can find several instances where Chrome engineers point out that Click-to-Play is not meant to be a security feature, and that the "Block all" setting is what is actually secure. There are several bugs which demonstrate ways around Click-to-Play which are closed as "WontFix". A quick search yields the following quotes from Chrome engineers:
"Yes, this is why click-to-play is designed as a convenience and not a security feature. If you want plugins blocked in a way that cannot be click-jacked, use "Block all," which requires a protected browser interaction (context menu, page action, etc)." [0]
"The "Click to play" setting is not a security measure. If you want to securely block plugins you must use the "Block all" option, which is a bit less convenient than "Click to play," but provides a click-jack resistant, browser mediated interface." [1]
"I'm kicking this out of the security queue because it isn't a security mechanism ... The secure method of blocking plugins is to select "Block all" and right-click to run. Whereas the "Click to play" feature is for convenience and performance." [2]
"It's not a security feature..." [3]
[0]: https://code.google.com/p/chromium/issues/detail?id=176724
[1]: https://code.google.com/p/chromium/issues/detail?id=225636
[2]: https://code.google.com/p/chromium/issues/detail?id=160707
[3]: https://code.google.com/p/chromium/issues/detail?id=414232
I'm sure there are other instances where they talk about it more, these are just the first results I found.