is a trade-off, I worked from home for a year, and although I missed the casual interactions you get in the office, I was able at any moment to take a 5 minute break to play with my kids, go pick them up from school, help them with homework, and that's priceless
It's definitely not for everyone. In my work 90% of the people I interact with are working remotely, so working from home half of the week doesn't really affect me. Not having to commute in the morning has a profound effect on my mood. I've also learned that rolling out of bed and just plunking down to work makes me less productive than getting up and showering and putting on at least some casual clothes. However I also have a wife and kids that come home after I'm done with work, so I'm not fully isolated all day.