If you need color accuracy then you're calibrating your monitor hardware.
People using Macs certainly do care about ColorSync. That’s the name of the software which uses the display characterization to keep colors looking as expected throughout the operating system and most applications.
Using LUTs either at the application or OS level to adjust colour information is a big no-no, although that doesn't stop some people from doing it. You simply don't want to change your colour space[1] until you absolutely have to.
The point of calibrating your monitor (which is a hardware + firmware level problem) is to see how your RGB image will look on a colour space restricted piece of hardware (for example in video this is often 12-bit RGB --> Rec709).
