Without knowing your use case it is hard to say
1) do you want to do more native stuff, do you need the additional performance.
2) or are you just building any web capable user interface
3) do you need to simultaneously push to web and native
4) do you need to push to both ios and Android
5) Finally layer in the talent of your team, what are their strengths, you pick the lowest common denominator.
As you start talking in terms of functionality, platform and team strength you will start to answer that question yourself
