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I'd like to share a series of blog posts from AWS about best practices in using Spot and building cost effective applications.
We've worked hard to put all learned over last few years about Spot into concise and easy to digest best practices, and I hope that it would help build better applications and scale for less!
https://aws.amazon.com/blogs/aws/building-price-aware-applications-using-ec2-spot-instances/
https://aws.amazon.com/blogs/aws/focusing-on-spot-instances-lets-talk-about-best-practices/
https://aws.amazon.com/blogs/aws/amazon-ec2-spot-fleet-api-manage-thousands-of-instances-with-one-request/
https://aws.amazon.com/ec2/spot/bid-advisor/