vapemaster

Claude Opus has started refusing to answer any moderately detailed question regarding biotech / drug discovery related tasks. Sonnet will still answer but at it's usual level of inaccuracy and vagueness that makes it unhelpful. Why would this pose a safety concern? What am I missing.

ie prompt: I have a small molecule I want to optimize oral bioavailability for in cynos and humans, what is the best formulation including novel excipients and permeation enhancers to achieve this?

Response: Claude is unable to respond to this request, which appears to violate our Usage Policy. Please start a new chat.

I'm in the drug discovery space, and for all the "engineering biology" talk that's around these days, I find a bunch of parallels to drug discovery in the AI, particularly LLM space.

The fact that these models get created and the poked and prodded with prompts reminds me a ton of chemical biology, aka the field of using chemicals to investigate biology.

It would appear that in the case of AI, the engineering has become art.

Ironically these technologies are the ones being heralded as the way to take biology and turn it into an engineering problem.

I always come back to may favorite XKCD "Here to Help" https://xkcd.com/1831

Long time windows + occasional linux user. Switched to Mac for the M2 Mac Book Air. It's a phenomenal piece of silicon + hardware.

Fairly shallow learning curve on the switch since so much is cross platform electron apps these days.

BUT ... Good god the command vs ctrl behavior is driving me nuts! (even with tweaking using Karabiner etc.)

First, the ergonomics of ctrl (left pinky stretch) + any letter vs command (left thumb inversion) are night and day. ctrl for the win.

Second - windows is so much more consistent for what the ctrl key does vs the super (windows) does. ctrl is almost always the modifier, Windows key is always OS level. Mac, it's all over the place.

Am I just still on the learning curve and cranky, or does this seem like a worse user experience to any other dual wielders?

so much of my time is spent in chrome tabs / windows / and searches. someone's average chrome tab count is a badge of honor / horror. Chrome now hides the bookmark bar by default. you can create tab groups for a session, or pin them so that they consume all your bandwidth and memory next time you open your session.

But that's not what i want.

i want rich bookmark behavior.

i want to be able to quickly load common favorite news sites & blogs.

or load a window with all my productivity SaaS sites.

or pick up where i left off on a research rabbit hole.

and i want it to be intuitive, efficient, and a prominent UX feature set.

i'm not alone right?